Hela Ferjani

Synthesis, modelling, biological activity of new thiophene hybridized with pyrazole, and/or pyridine analogues as potential DNA gyrase and topoisomerase IV inhibitors

Promoted by the well-established, valuable biological activity of thiophene-based hybrids, the study displayed the synthesis of two series of thiophene-pyrazole hybrids, 7a-c and thiophene-pyridine hybrids 9a-c, via reacting arylhydrazone with halogenated reagents and nucleophili...