Heba Abouelyazied Khafagy

Acute kidney injury-to-chronic kidney disease transition: Maladaptive senescence, epigenetic reprogramming, and the translational frontier

Acute kidney injury (AKI) is a consistent precursor of incident and progressive chronic kidney disease (CKD). The transition reflects failed tubular repair followed by tubular atrophy, peritubular capillary rarefaction, and progressive interstitial fibrosis. Maladaptive cellular...

The interplay of the gut microbiome, tryptophan metabolites, and uremic toxin generation in chronic kidney disease progression

Chronic kidney disease (CKD) affects roughly 850 million people worldwide, yet the cardiovascular and immune-related mortality that classical uremic markers cannot fully explain remains the central clinical problem. Much of the small-solute uremic toxin pool is now traceable to g...