Hayato Laurence Mizuno

A Programmable Nanovesicle Platform for MegapascalPressure Sensing

Abstract Hydrostatic pressure (HP) is a subtle yet pervasive force that shapes chemistry and biology from the ocean floor to living cells─yet real-time HP sensing at the microscale remains elusive. Here, we report pyrene-modified polyionic complex vesicles (Pyr-PICsomes) as a cla...

Stable core-encapsulation of indium-111 in crosslinked polyionic complex micelles and assessment of its biodistribution

Radioactive isotopes, such as Indium-111 ( 111 In), are pivotal for highly sensitive noninvasive imaging and targeted radiotherapy. However, achieving stable in vivo retention remains a critical barrier. Conventional nanocarriers typically rely on surface-bound chelators, exposin...