Harrison J. Esterly

Decongested 2D IR Spectra Reveal N-Terminal Helices in Amyloid Oligomers Associated with Type 2 Diabetes

Abstract Oligomeric peptides are implicated in amyloidosis, yet only a few atomic structures of amyloid oligomers have been identified. Recently, we reported an atomic structural model of human islet amylin polypeptide (hIAPP) oligomer [Shivani, S. T.; et al.Proc. Natl. Acad. Sci...