Harish Kannan

Global proteolysis during starvation governs proteome remodeling and a survival–regrowth trade-off in bacteria

Starving bacteria must synthesize stress proteins to survive, but how protein synthesis persists in the absence of nutrient influx is unclear. We show that in Escherichia coli , carbon starvation triggers large-scale proteome remodeling, with global proteolysis supplying both the...