Haoyu Chao

A systems-level dissection of aging and longevity mechanisms powered by an evidence-routed AI knowledge graph

Abstract Aging is a complex biological process influenced by numerous molecular and cellular factors. A systems-level understanding of these mechanisms is essential for identifying key regulatory processes and prioritizing effective interventions. Here, we present a comprehensive...

Machine Learning-Guided Stress Atlases Reveal Co-Expression Rewiring and Divergent Cellular Deployment of Abiotic Stress Programs in Rice and Wheat

Abiotic stress limits cereal productivity, yet whether conserved stress-responsive genes retain similar transcriptional network organization and cellular deployment across cereal species remains unknown. Here, we developed a machine learning-guided comparative framework to integr...