Haotian Liu

Hsc70-Mediated Targeting Chimeras for Targeted Protein Degradation via Chaperone-Mediated Autophagy

Abstract Despite the remarkable success of proteolysis-targeting chimeras (PROTACs), challenges such as limited applicability to certain cytosolic proteins, potential resistance risks, and off-target effects remain. Novel degradation strategies harnessing the autophagy/lysosome p...

Epigenetic regulation of NLRP3 by ACLY–PLAC8 axis sustains metabolic adaptation in triple-negative breast cancer

Abstract Cell metabolism is intricately interconnected with various pathological processes, including metabolic disorders, chronic inflammation, and tumor progression. Dysregulated lipid metabolism can result in mitochondrial dysfunction and excessive reactive oxygen species accu...