Haojun Xiong

SIRT2-mediated deacetylation of ANT3 at Lys96 promotes cell death

Abstract ANT3 is a key molecule that constitutes the mitochondrial permeability transition pore (mPTP) and mediates cell death. Disruption or conformational changes in ANT3 protein homeostasis can trigger cell death. However, the molecular mechanism of ANT3 protein homeostasis re...

Phosphorylation of OTUB1 promotes autophagy initiation under starvation

Eukaryotes initiate autophagy in response to environmental challenges such as nutrient deprivation. However, the mechanisms governing autophagy initiation remain incompletely understood. Here, we demonstrated that OTUB1 phosphorylation plays a key role in starvation-induced autop...