Hao Xu

Enantioconvergent Assembly of Chiral Difluoromethyl Stereocenters by Nickel-Catalyzed Reductive Cross-Coupling

Abstract The catalytic asymmetric construction of C(sp3)–CF2H stereocenters remains a longstanding challenge in synthetic and medicinal chemistry. Herein, we report a nickel-catalyzed enantioconvergent reductive cross-coupling strategy that enables efficient access to chiral difl...

Enantioselective Convergent Synthesis of Heterohelicenes via Copper-Catalyzed Propargylic Annulation/Acid-Promoted Aromatization

Abstract Heterohelicenes combine helical chirality with tunable electronic properties, making them attractive for applications in chiral materials and optoelectronics. However, their enantioselective synthesis, particularly for five-membered heterohelicenes, remains a long-standi...