Hao Wu

Twist Family BHLH Transcription Factor 1 orchestrates hypoxia-lactate crosstalk to bridge glycolytic flux and tubular maladaptation in fibrotic kidneys

Abstract The reprogramming of glycolytic metabolism is essential for maintaining the reparative homeostasis of tubular epithelial cells (TECs). Maladaptive TEC repair mechanisms drive the progression from acute kidney injury (AKI) to chronic kidney disease (CKD). Twist Family BHL...