Hao Wang

Cannabinoid CB1 Receptor in Nociceptors Mediates Postoperative Analgesia via ASIC3 Inhibition

ABSTRACT Peripherally restricted analgesics devoid of central side effects are urgently needed for postoperative pain management. The cannabinoid type‐1 receptor (CB 1 R) expressed on primary sensory neurons represents an attractive peripheral target, yet its specific role and me...

ALKBH5-Dependent m 6 A Demethylation Promotes Cardiac Aging Through SLC38A3 Reduction and Glutamine Metabolic Alteration

BACKGROUND: N 6 -methyladenosine (m 6 A) modification has been linked to various types of physiological and pathological bioprocesses. However, the exact role of m 6 A mRNA methylation in cardiac aging is largely unknown. Here, we show that ALKBH5 (alpha-ketoglutarate-dependent d...