Hao Chai

Research and advances in TK1-mediated metabolic reprogramming in modulating the tumor immune microenvironment in hepatocellular carcinoma

Abstract Hepatocellular carcinoma (HCC) is still one of the leading causes of cancer-related deaths in the world. It is characterized by significant metabolic disorders and immunosuppressive tumor microenvironment(TME). As a key enzyme in the thymidine remedy pathway, TK1 is trad...