Hanzhe Zhang

Mitochondria-ER contact sites in neurodegeneration: a homeostatic hub linking metabolic stress, neuroinflammation, and therapeutic opportunities

Neurodegenerative diseases (NDDs) involve self-amplifying interactions among proteotoxic stress, mitochondrial dysfunction, and neuroinflammation. Emerging evidence increasingly implicates mitochondria-endoplasmic reticulum contact sites (MERCs) as dynamic homeostatic hubs that m...