Hangping Yao

Single-Tube Six-Channel Ultrafast PCR with Melting-Curve Discrimination for Seven Respiratory Pathogens

Abstract Expanding single-tube multiplexing beyond the number of fluorescence channels on a real-time PCR instrument is a persistent challenge for point-of-care testing (POCT). Here, we break this barrier by leveraging melting temperature (Tm) as an extra information dimension. B...

Functional mapping of IFITM3 resolves its antiviral core and deciphers human influenza susceptibility

Genetic variation in interferon-induced transmembrane protein 3 (IFITM3) contributes to inter-individual differences in influenza outcome, yet a comprehensive functional map of IFITM3 variation remains unavailable. Here we show a high-resolution functional atlas of 2,898 IFITM3 v...