Hana M. Dobrovolny

Estimation of SARS-CoV-2 Viral Dynamics Parameters in Favipiravir-Treated Cynomolgus Macaques: Comparison of Individual and Group Average Model Fitting

Favipiravir, an antiviral that inhibits viral RNA-dependent RNA polymerase, has demonstrated promise as a therapeutic for RNA viral infections such as SARS-CoV-2. Mathematical modeling of viral kinetics provides a tool for analyzing the progression of viral infections and the act...

Modeling the interferon response to avian influenza

Highly pathogenic avian influenza viruses, such as H5N1, cause severe disease in humans and pose a persistent pandemic threat, yet the mechanism by which the type I interferon response shapes their within-host dynamics remains unclear. Here we fit three ordinary differential equa...