Han Xie

Lactate‐Induced K370 Lactylation of STING Inhibits STING‐TBK1 Signaling and Dampens Anti‐Tumor Immunity

ABSTRACT The stimulator of interferon genes (STING) pathway represents a central component of innate anti‐tumor immunity; however, the efficacy of STING‐targeted therapies is frequently limited by tumor‐intrinsic resistance mechanisms. Here, we identify lactate‐driven lactylation...

Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer

Dual-target c-Met/VEGFR kinase inhibitors have emerged as promising therapeutic agents for cancer therapy, although their underlying antitumor mechanisms remain poorly defined. In this study, we demonstrate that foretinib, a selective c-Met/VEGFR2 inhibitor, triggers immunogenic...