Han Gong

Spatial multiomics uncovers an SPP1+ macrophage-driven anti-apoptotic niche in osteoarthritis synovium via the SPP1-CD44 axis

This BioProject includes spatial transcriptomics data from human osteoarthritis (OA) and normal synovium, as well as RNA-seq data from mouse RAW264.7 cells treated with OPN, to investigate the functional subsets and spatial niches of synovial macrophages. Background: Osteoarthrit...

Magnetotactic bacterial-reprogrammed TCR-macrophages for durable anti-tumor photoimmune therapy

Macrophage have shown great promise in the clinical treatment for head and neck cancer (HNC). However, macrophage therapies confront significant hurdles due to a deficiency of tumor-specific targets and tumor resistance. Herein, we report the development of a magnetotactic bacter...