Halis Süleyman

Exogenous ATP Attenuates Biochemical and Histological Markers of Osimertinib-Associated Myocardial Injury in Rats

(1) Background: Osimertinib is an effective third-generation EGFR tyrosine kinase inhibitor, but its clinical use may be limited by cardiotoxicity. This study investigated the relationship between reduced measured cardiac ATP levels and osimertinib-associated cardiac injury and e...

Protective effects of flunarizine and ATP against pembrolizumab-associated gastric injury in rats

Abstract Pembrolizumab, an immune checkpoint inhibitor targeting pro-grammed cell death protein-1 (PD-1), is widely used in cancer therapy. However, its potential gastrotoxic effects and underlying molecular mechanisms remain poorly understood. Flunarizine has antioxidant, calciu...