Haiyu Yan

Mortality-trained MRI brain age acceleration mediates sex-specific associations between health-related phenotypes and incident dementia

Abstract Background Brain age acceleration (BAA) has emerged as a promising neuroimaging marker of brain health and neurodegeneration. However, most existing brain age models are trained to predict chronological age, which may not be the most clinically relevant target. In this s...

Metabolomic Profiling of Telomere Length: Associations with Aging-related Phenotypes and Modifiable Lifestyle Factors in Chinese Older Adults

BACKGROUND: Telomere length (TL) is a well-established biomarker of cellular senescence, yet the metabolic profile of TL and its associations with aging-related phenotypes and responses to modifiable lifestyle factors remain unclear. METHODS: TL was measured using quantitative re...