Haiwei Yang

Targeting ADAR1 reprograms cold tumors to hot and enhances immunotherapy in bladder cancer

Despite significant advances in immunotherapy for certain solid tumors, bladder cancer (BCa) exhibits limited responsiveness, primarily due to its highly immunosuppressive “cold” tumor microenvironment (TME). The role of Adenosine Deaminase Acting on RNA1 (ADAR1) in regulating BC...