Haishui Shi

Therapeutic targeting of TCF/LEF transcription factors in neuropsychiatric disorders via Wnt/β-catenin signaling

The T-cell factor/lymphoid enhancer-binding factor (TCF/LEF) family, comprising TCF1, LEF1, TCF7L1, and TCF7L2, serves as nuclear effectors of the canonical Wnt/β-catenin signaling pathway and plays pivotal roles in neurodevelopment, synaptic plasticity, neuroinflammation, and ce...