Hairui Tian

Ultrasound-activated Cu2−XSe/TiO2 heterostructured nanosonosensitizer enables coordinated induction of ferroptosis and cuproptosis for tumor immunotherapy

Triple-negative breast cancer (TNBC) is a highly aggressive subtype characterized by the absence of actionable molecular targets, high metastatic propensity, and limited responsiveness to current immunotherapies. Although immune checkpoint inhibitors show promise, their clinical...

Porcine Sertoli cell exosomes tune the redox setpoint of spermatogonial stem cells through PSMD11–p38 MAPK signaling to mediate differentiation

Spermatogonial stem cell (SSC) fate—the choice between self-renewal and differentiation—is governed by intercellular signaling within the testicular niche. A central paradigm holds that endogenous reactive oxygen species (ROS) sustain SSC self-renewal through MAPK signaling. Yet...