Guzin Demirağ

Prognostic significance of folate receptor alpha expression in endometrial serous carcinoma: implications for patient stratification and targeted therapy

Abstract Objective To evaluate the clinical significance of folate receptor alpha (FRα) expression in endometrial serous carcinoma. Methods We retrospectively analyzed 47 patients with histopathologically confirmed endometrial serous carcinoma who underwent hysterectomy and recei...

Penile metastasis from rectal cancer: a case report

Penile metastasis is extremely rare despite the rich vascularization of the organ. The majority of metastatic lesions originate from adjacent genitourinary and pelvic organs, particularly the bladder, prostate, and rectosigmoid colon (28.6%, 27.9%, and 12.2%, respectively). In ad...

Impact of adjuvant endocrine therapy on disease-free survival in early triple-positive breast cancer: a multicenter retrospective cohort study of the Turkish oncology group

Triple-positive breast cancer (TPBC), characterized by concurrent ER, PR, and HER2 positivity, poses unique therapeutic challenges due to ER–HER2 crosstalk. The optimal adjuvant endocrine therapy in TPBC patients receiving anti-HER2 regimens remains poorly defined. This multicent...