Guy A. Caldwell

An atfs-1 loss-of-function screen identifies novel regulators of α-synuclein toxicity in C. elegans dopaminergic neurons

Abstract Overexpression of α-synuclein (α-syn), an inherently disordered protein, triggers chronic activation of the mitochondrial unfolded protein response (UPRmt) pathway in Caenorhabditis elegans with enhanced dopaminergic (DAergic) neurodegeneration. Introduction of a loss-of...