Gurunath Ramanathan

Bifunctional architecture enables substrate catalysis and channeling in Paracoccus TMAO demethylase

Substrate channeling enhances efficiency and prevents toxicity by directing unstable intermediates between active sites. Trimethylamine N-oxide demethylase (TDM) degrades trimethylamine N-oxide (TMAO) to dimethylamine and formaldehyde (HCHO), but the fate of HCHO has remained unc...