Guojiao Wu

Photoenzymatic Enantioselective [2+2] Cycloaddition of Alkynes Enabled by Whole-Cell Directed Evolution

Abstract Enantioselective excited-state photocycloadditions represent an attractive yet challenging strategy for accessing optically active strained molecules. Here, we report a whole-cell directed evolution platform for engineering artificial triplet photoenzymes that catalyze t...