Guohua He

Mutations in EnvZ, KPC, and OmpK36 contribute to the evolution from ceftazidime-avibactam heteroresistance to stable resistance in carbapenem-resistant Klebsiella pneumoniae

Antibiotic heteroresistance, an unstable phenotype wherein a minority-resistant subpopulation coexists with a majority-susceptible population, can evolve to stable resistance following in vivo antibiotic exposure, thereby substantially increasing the risk of treatment failure. Ho...