Guilherme Caldas de Andrade

Biomolecules under Pressure: Protein Phase Transitions from Folding to Misfolding, Aggregation, and Condensation

Abstract High hydrostatic pressure provides a unique and sensitive perturbation to protein structure, enabling direct measurement of volume changes associated with folding, misfolding, and assembly. Because pressure perturbs noncovalent forces while preserving covalent integrity,...