Guibin Jiang

Machine Learning-Assisted Key Toxicant Identification from Mass Spectra: A Case Study of AhR Agonists in Polypropylene Face Masks

Abstract Identifying key toxicants that drive biological effects in complex samples remains a major challenge for environmental analytical chemistry. Here, we developed an AhR-oriented machine-learning model, EIMSFrag-AhR, to predict AhR agonistic activity directly from GC-EI-MS...

Toxicokinetics, Biotransformation, and Tissue Distribution of Imidaclothiz in Rats

Abstract Imidaclothiz (IMZ), a next-generation neonicotinoid pesticide, has garnered significant attention due to its detection in human samples. In this study, we investigated its toxicokinetics and biotransformation in rats following oral administration. IMZ was rapidly absorbe...

Structure-Related Activity of 4-Alkylphenols in Hepatic Lipogenesis Regulated by Estrogen Receptor Agonism and Oxidative Stress

Abstract 4-Alkylphenols (APs), as typical endocrine-disrupting chemicals (EDCs) widely present in the environment and the human body, have been implicated in the disruption of lipid metabolism. However, the structure-activity relationships (SARs) and underlying mechanisms of thei...