Guangzhu Wang

Chiral Arylthiol-Catalyzed Asymmetric Hydrodifluoroalkylation of Alkenes Facilitated by Noncovalent Interaction

Abstract Chiral gem-difluorinated indane scaffolds are valuable fluorinated bioisosteres of medicinally important CH2-containing indane frameworks. Herein, a photodriven enantioselective hydrodifluoroalkylation of methyleneindanes with α-bromodifluoroamides catalyzed by a C2-symm...