Grzegorz L. Ciesielski

Structural and single-molecule insights into the core human mitochondrial DNA replisome.

Replication of human mitochondrial DNA (mtDNA) is essential for the maintenance of oxidative phosphorylation and cellular energy homeostasis. Impairment of this process leads to mtDNA deletions, depletion, and point mutations that underlie a broad spectrum of mitochondrial diseas...