Grzegorz R. Kudla

3D confinement reshapes RNA folding and enhances circularization in the Zika virus

Abstract Many RNA molecules function within confined environments, but the effect of confinement on RNA folding remains poorly understood. Proximity ligation experiments reveal altered long-range contacts in confined versus unconfined states, yet they do not explain how spatial c...

Identification of cellular double-stranded RNAs in mammalian embryonic stem cells

Abstract Antiviral defence mechanisms are typically activated upon sensing virus-derived nucleic acids. During replication, viruses generate double-stranded RNA (dsRNA) intermediates that the innate immune system can sense, triggering several defence pathways. Conversely, mammali...