Graeme R. Grimes

The moonlighting functions of SEC13 in nonsense-mediated mRNA decay and the regulation of ER stress

ABSTRACT The nonsense-mediated decay pathway (NMD) is an RNA quality control mechanism that regulates the stability of target RNAs. We previously identified the ER-localized SEC13 protein as a novel NMD factor in C. elegans and in HeLa cells; raising the possibility that it could...