Gracie Siffer

Ligand-tuned extracellular domain dynamics are correlated with signaling states in an adhesion GPCR

Adhesion G protein–coupled receptors (aGPCRs) transduce signals via engagement of their large extracellular regions (ECRs) with adhesion partners. ADGRG6 (GPR126) is an aGPCR vital for the development of multiple organs and myelination. ECR conformational dynamics of ADGRG6 has b...