Giulia Piazzi

Omega-3 polyunsaturated fatty acids and epigallocatechin-3-gallate attenuate obesity-associated CD44-high stemness in colorectal cancer through modulation of Notch1, Wnt/β-catenin and PI3K/mTOR signaling

Obesity is a major risk factor for colorectal cancer (CRC), promoting tumor initiation through chronic inflammation and metabolic dysregulation. Cancer stem cells (CSCs) drive CRC progression through Notch1, Wnt/β-catenin (Wnt), and PI3K/mTOR (mTOR) signaling. Omega-3 polyunsatur...