Giovanni Savarese

PIK3CA in Cancer: Structure, Biology, Alterations, and Actionability

PIK3CA, which encodes the p110α catalytic subunit of phosphoinositide 3-kinase (PI3K), is one of the most frequently altered oncogenes in human cancer and a major driver of tumor initiation, progression, metastasis, and therapeutic resistance. Over the past two decades, advances...

Does Gut-Endometrial Immunomodulation Promote Pregnancy in IVF Patients with Recurrent Implantation Failure and Chronic Endometritis Following Escherichia coli Nissle 1917?

Background: Recurrent implantation failure (RIF) remains one of the most challenging conditions in reproductive medicine. Although increasing evidence implicates chronic endometritis (CE) and alterations of the endometrial microbiota in impaired implantation, the potential contri...