Giovanni Sarnelli

Palmitoylethanolamide as an Intestinal Gatekeeper: Linking Inflammation, Angiogenesis and Colorectal Cancer Interception

Angiogenesis is a major determinant of tumor growth, progression and metastatic potential, and its persistent activation is closely intertwined with chronic inflammation. This relationship is particularly relevant in malignancies that arise through a prolonged inflammation-to-car...

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

ABSTRACT Functional dyspepsia (FD) is a common disorder of gut‐brain interaction in which gastric sensorimotor abnormalities may coexist with impaired duodenal barrier function, low‐grade immune activation, and altered neuroimmune signaling. Peroxisome proliferator‐activated rece...

Engineered PEA-producing Lactobacillus paracasei F19 prevents colitis-associated colorectal cancer in mice by modulating inflammatory–angiogenic signaling and beneficially reshapes gut microbiota composition

Colitis-associated colorectal cancer (CAC) arises from the interplay between chronic inflammation, epithelial dysregulation, angiogenesis, and microbiota alterations. Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inflammatory and anti-angiogenic properties...