Giovanni Balice

S. cerevisiae Cwc15p Tunes the Spliceosome Active Site for Remodeling and Catalysis

Abstract Pre-mRNA splicing is an essential step in eukaryotic gene expression during which spliceosomes remove introns from nascent RNAs while ligating the adjacent exons. Spliceosomes are cellular nanomachines composed of five small nuclear (snRNA) components and dozens of prote...