Giorgia Sciacca

Long-Duration Response to Levodopa in Patients with Early Parkinson’s Disease: Pharmacodynamics, Neuroplasticity, and Clinical Implications

Background: The most effective pharmacological treatment for Parkinson’s disease (PD) remains levodopa, whose responsiveness is distinguished into two temporally and mechanistically distinct components: the short-duration response (SDR), which lasts hours, closely paralleling dru...