Gioele La Manno

Computational deconvolution of drug sensitivity via single-cell–to–bulk transcriptome mapping

Analyses routinely conducted in both fundamental research and biomedical studies often report aggregate signals derived from heterogeneous mixtures of cells. These mixtures reflect the intrinsic anatomical and functional complexity of the tissues and organs from which they are de...

The lipidomic architecture of the mouse brain

Abstract Lipids are fundamental components of the brain, crucial for synaptic transmission and signal propagation. Altered brain lipid composition is associated with common and rare neuropathologies, yet the spatial organization of the mammalian brain lipidome remains insufficien...