Gillian Coughlan

Reproductive Lifespan and Hormonal Therapy in Relation to Later-Life Neurovascular Health in Community-Dwelling Older Women

ABSTRACT Background Women face greater vulnerability to dementia and Alzheimer’s disease (AD), potentially due to estrogen fluctuations across the lifespan. However, its role in vascular brain health is unclear. We investigated associations between lifelong estrogen exposure—endo...

Longitudinal associations of hormone therapy and depressive symptoms in cognitively unimpaired older women

Abstract Background Women are disproportionately affected by depressive disorders relative to men, and mid-life differences like menopause can exacerbate symptoms. Hormone therapy (HT) is a common treatment to ease menopause transitions, including vasomotor and depressive symptom...