Gianluigi Savarese

The 2026 ESC heart failure guidelines: advancing science while facilitating clinical implementation

The 2026 European Society of Cardiology (ESC) guidelines for the management of heart failure introduce a series of important changes intended to simplify classification, accelerate implementation of effective therapies, and shift care toward earlier prevention and intervention. A...

Adherence and Healthcare Costs Associated with Single-vs Free-Pill Combination of Perindopril-Based Antihypertensive Medications: An 11-Year Follow-Up, Real-World Evidence

BACKGROUND: Short-term studies have demonstrated that single-pill combinations (SPCs) improve adherence, reduce hypertension-related complications, and lower costs; however, long-term benefits remain unclear. This study compared adherence, healthcare resource utilization (HCRU),...