George Krasopoulos

Interactions Between Health Inequalities on the Management and Outcomes of Thoracic Aortic Disease in England: A National Cohort Study

BACKGROUND: The aim of this study was to evaluate the intersectionality between measured causes of health inequality and clinical factors that influence treatment decisions and regional variations in care and survival for people with thoracic aortic disease (TAD) in England. METH...

Peroxiredoxin-6 protects against oxidative stress-mediated hypertrophic remodeling in JPH2-A399S knock-in mice

Background Most mutations causing hypertrophic cardiomyopathy (HCM) affect sarcomeric proteins. Mutations in junctophilin-2 (JPH2) are also implicated, but the underlying mechanisms remain unclear. An A405S variant in JPH2 was identified in a male adolescent patient with interven...

Optimising glycaemic control in cardiac surgery: narrative review and author recommendations

Abstract Objectives Diabetes and peri-operative hyperglycaemia are associated with increased morbidity and mortality following cardiac surgery. Despite this, specific guidance on peri-operative glycaemic management during cardiac surgery is lacking in United Kingdom (UK) and Euro...