Georg Juckel

Using multi-trait polygenic scores to predict lithium responsiveness in patients with bipolar disorder

Background The predictive power of polygenic scores (PGSs) for lithium treatment response in bipolar disorder remains limited. Aims To enhance the prediction of lithium responsiveness by developing a multi-trait PGS (mt-PGS) combining genetic information from multiple phenotypes...

Diagnosing autoimmune encephalitis in psychiatry: clinical recommendations and unresolved challenges from the GENERATE network

Psychiatric syndromes can be caused by underlying autoimmune encephalitis (AE). This represents a diagnostic challenge at the interface of psychiatry and neurology. While AE mostly manifests with a combined, complex neuropsychiatric syndrome, some patients with AE may (initially)...

Deep Brain Stimulation Modulates Nucleus Accumbens Theta-Band Power in a Rodent Model of Schizophrenia

Background/Objectives: Deep brain stimulation has proven a powerful treatment option for various neuropsychiatric diseases. In psychiatry, this is particularly relevant for schizophrenia, where up to one third of patients do not respond to current treatment options. To further un...

Analysis of brain volumetry and functional connectivity during resting state in patients with borderline personality disorder

Abstract Background Borderline Personality Disorder (BPD) involves affective instability, impaired emotion regulation, and self-injurious behavior, often linked to childhood adversity. Although prefrontal and insular abnormalities have been reported, the relationship between stru...

Empathy for pain processing in individuals with elevated internet addiction scores: an event-related potential study

Abstract This study aimed to comprehensively elucidate patterns of empathy impairment using self-report, performance-based, and electrophysiological measures, alongside two cognitive measures, in individuals with elevated internet addiction (IA) scores (HIA, n = 20) compared to t...