Genki Amano

The protein disulfide isomerase P4HB/PDIA1 modulates cellular and misfolded forms of the prion protein

Prions are misfolded, self-propagating versions of cellular proteins. In humans and animals, misfolding of the cellular prion protein (PrP C ) causes invariably fatal transmissible neurodegenerative diseases. Little is known about how mammalian prions replicate in the brain, incl...