Gaurav Nandagawli

A Computational Framework for Erythropoietin Protein Synthesis and Optimization: Integrating Protein Language Models, AlphaFold3 Structural Prediction, and Bayesian Optimization

Erythropoietin (EPO) is a 166-residue, four-helix-bundle glycoprotein hormone that regulates erythropoiesis and remains one of the most clinically significant recombinant biopharmaceuticals in use today. Despite four decades of structural and pharmacological characterization, the...