Gareth J. Howell

Deletion of a rheumatoid arthritis risk enhancer in mouse disrupts Bim expression and immune homeostasis

Objectives This study aimed to characterise the in vivo function of a murine regulatory region syntenic to the human rheumatoid arthritis (RA)-associated enhancer at the ACOXL locus and its role in immunity. Methods Using CRISPR-Cas9, we generated the Bim-eΔ mouse model by excisi...