Gar Yee Koh

Dietary Fructooligosaccharide Is Associated with Improved Insulin Resistance, Reduced Romboutsia ilealis Abundance, and Modulation of GLP-1 Production in High-Fat Diet-Induced Obese Mice

Background/Objectives: Obesity disrupts glucose homeostasis and insulin signaling, partly through altered gut hormone secretion and intestinal inflammation. Our previous work demonstrated that fructooligosaccharides (FOS), a prebiotic fiber, suppressed colonic inflammation, and m...

Beyond Vitamin D Deficiency: Maternal Diet, Metabolic Dysfunction, and Vitamin D Signaling in Developmental Programming

Within the Developmental Origins of Health and Disease (DOHaD) framework, maternal nutrition is an important component of the developmental environment that can shape long-term offspring metabolic and immune health. Western dietary patterns (WD), characterized by high energy dens...