Gaowa Bao

Flt3-dependent mitochondrial transfer from macrophages alleviates heart failure after myocardial infarction through SEC22B de-ISGylation

Abstract Fms-related receptor tyrosine kinase 3 (Flt3) is upregulated in ischemic hearts, yet its macrophage-specific role in post-ischemic remodeling remains unclear. Here, we identify macrophages as the predominant Flt3-expressing cells in the infarcted heart and demonstrate th...