Gaoning Zhang

Enhancing Natural Product Therapy with PROTACs: Targeted Degradation of TLR4 Confers Potent Endothelial Protection

Abstract TLR4-MyD88-mediated endothelial dysfunction drives cardiovascular disease. To overcome the weak efficacy of ferulic acid, we synthesized six ferulic acid-based PROTAC derivatives. Migration and TLR4 expression assays in HUVECs identified FP-4 as lead. FP-4 induced the ta...